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Furthermore, chronic inflammation due to long-term smoking may promote liver fibrosis and other pathological changes 30,31 , accelerating the progression of viral hepatitis

There are still some outstanding questions that only long-term data can answer

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In this study the investigators exposed rats to nicotine free (0 mg/ml) or nicotine containing (18 mg/ml) e-cigarette vape, and two different numbers of puffs (20 or 60 puffs/day) to address the nicotine-, and dose-dependent effects